Female Estrogen Estriol Anabolic Steroid Hormones CAS 50-27-1, Pharmaceutical Grade
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- Model NO.: 50-27-1
- Customized: Non-Customized
- Suitable for: Adult
- Purity: >99%
- Transport Package: as Your Required
- Powder: Yes
- Certification: GMP, ISO 9001
- State: Solid
- Trademark: YC
- Origin: China
Synonyms: Oestriol; 1, 3, 5(10)-Estratriene-3, 16a, 17b-triol
CAS No.: 50-27-1
ECNECS No.: 200-022-2
Melting Point: 281-282º C
Boiling Point: 469 ° C at 760 mmHg
Refractive Index: 1.624
Flash Point: 220.8 ° C
Appearance: White crystalline powder
Grade: Pharmaceutical Grade
Storage: Shading, confined preservation
Lead time: Within 12 hours upon receipt of payment
Delivery: EMS, DHL, TNT, FedEx, UPS
Usage: A metabolite of Estradiol. An estrogenic metabolite considerably less potent than the hormone Estradiol. Pharmaceutical material, Steroid hormone, estrogen.
Estriol can be a weak or strong estrogen depending on if it is given acutely or chronically when given to immature animals, but is an antagonist when given in combination with estradiol.
Estriol may play a role in the development of breast cancer, but based on in vitro research, does appear to act as an antagonist to the G-protein coupled estrogen receptor. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy.
Estriol can be measured in maternal blood or urine and can be used as a marker of fetal health and
wellbeing. is produced by the adrenal cortex of the fetus. This is converted to estriol by the placenta.
If levels of unconjugated estriol (uE3 or free estriol) are abnormally low in a pregnant woman, this may
indicate chromosomal or congenital anomalies like Down syndrome or Edward's syndrome. It is included as part of the triple test & quadruple test for antenatal screening for fetal anomalies.
Because many pathological conditions in a pregnant woman can cause deviations in estriol levels, these screenings are often seen as less definitive of fetal-placental health than non-stress testing. Conditions which can create false positives and false negatives in estriol testing for fetal
distress include preeclampsia, anemia, and impaired kidney function.
|Character||White or almost white crystalline powder||White crystalline powder|
|Specific rotation||+54°to +62°||+59.9°|
|Completeness of solution||Clear and free from undissolved solid||Conforms|
|Identification||(1) complies by IR|
(2) complies by UV
|Residue on Ignition||Not more than 0.1%||0.05%|
|Loss on drying||Not more than 0.5||0.1%|
|Total impurities not more than 2.0%||<2.0%|
|Assay||It should contain 97.0% to 102.0% of C18H24O3 calculated on dried basis||98.4%|
|Particle size||It should be 90% below 30μm||Conforms|
|Conclusion||Conforms to USP36|
The typical oral dose used in Western Europe is 2 to 5 mg daily, but because much of it is "dumped" by
the liver immediately, this may only ultimately amount to ½ to 1 mg of estriol actually getting into the body.
Many clinicians use an estriol cream that delivers 2 to 5 mg. When made as a cream, the pharmacist
should indicate on the container how much cream it takes to provide the 2 to 5 mg of estriol.
When you deliver estriol to your body via a cream, it is delivered in a much steadier fashion, whereas given orally it is subject to all the variables of how the digestive system and the liver are working from hour to
An estriol cream that delivers 0.5 mg, used every other day, has been shown to be very effective for treating vaginal atrophy and urinary tract infections. Published studies show that 0.5 mg estriol delivered every other day for 2 weeks, is adequate for most women, and this is how estriol is used by most women in
The reason that estriol is used only every other day is because it doesn't clear from the body as fast as the other estrogens and therefore one dose will last for two days. Using it every day can result in excessively high levels. Although estriol does not absorb through the skin as rapidly as estradiol or estrone, studies have shown that topical delivery of estriol is about twenty times more efficient than oral delivery.
1.Estriol is a Safe and Effective Hormone for Menopausal Women with Hot Flashes and Vaginal Dryness
2.Estriol Protects Against Breast and Uterine Cancers
3.Estriol as a Replacement Estrogen in Breast Cancer Survivors
4.Estriol Prevents Vaginal Atrophy and Urinary Tract Infections
5.Estriol Does Not Cause Blood Clots
6.Estriol Protects the Skin From Aging
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